Atorvastatin is considered a moderate- or high-intensity statin depending upon the dose:A dose of 10 to 20 mg per day is considered moderate-intensity therapy with an expected LDL (low density lipoprotein) reduction of 30% to 50%. A dose of 40 to 80 mg per day is considered high-...
et al. CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin. Eur J Med Res 29, 539 (2024). https://doi.org/10.1186/s40001-024-02109-7 Download citation Received10 June 2024 Accepted14 October 2024 Published...
intensity statinsecondary prevention of cardiovascular eventsAims To compare the effectiveness and safety of 2 high-intensity atorvastatin doses (40 mg vs 80 mg) among acute coronary syndrome (ACS) patients.Rahhal, AlaaKhir, FadiAljundi, Amer HussienAlAhmad, YaserAlzaeem, HakamHabra, MasaAl-Shekh...
1g–i). This indicates that all three lipophilic statins tested, but not the hydrophilic statin, increase the phagocytic function of ARPE-19 cells. Atorvastatin increases the phagocytic function of ARPE-19 cells in a dose-dependent manner Our recent clinical study demonstrates that high-dose ...
The intensity of fluorescence is proportional to the intracellular levels of ROS. After atorvastatin treatments cells were incubated with pre-warmed basal medium containing 10 µM H2DCF-DA for 30 min at 37 °C. Stained cells were gently rinsed in basal medium and incubated again for 1...
0.731 in the saline group and the atorvastatin group (p < 0.05, Pearson’s correlation coefficient). These suggested that the intensity of CD31 expression was positively related to absorption of the SDH. The atorvastatin induced more MVD marked by CD31 along with a significant shrinkage of the ...
A combination of antiplatelet drugs with high-intensity statin therapy is a standard in patients with coronary events. Concomitant treatment with ticagrelor, a moderate CYP3A4 inhibitor, and CYP3A4-metabolized statins such as atorvastatin, might lead to an increased risk of muscle-related adverse eve...
Furthermore, the standalone statin treatment induced the disorganization of zyxin towards cytoplasmic diffused distribution in contrast to peripherally aligned control cells. The effect was exacerbated with the increase in PEF intensity. Standalone treatment with atorvastatin induced noticeable changes in the...
The intensity of the interactions between atorvastatin calcium and the functional monomers was preliminary assessed using computer-assisted molecular modeling, which is considered as a green screening strategy for the rational selection of the composition [58,59]. The estimated free energy of the binding...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, Schoenhagen P, Crowe T, Cain V, Wolski K, Goormastic M, Tuzcu EM[April 2006]. "Effect of very high-intensity statin therapy on regression of coronary atherosclerosis...