Patients should be carefully instructed in the use of topical glucocorticoids to avoid side effects.Conclusions: Treatment of atopic eczema should be based on a "stepped-care plan" where treatments are stepped up or down depending on the assessment of the state of the child's skin by the ...
Moniaga CS, Egawa G, Kawasaki H, Hara-Chikuma M, Honda T, Tanizaki H, et al. Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with dermatophagoides pteronyssinus extract. Am J Pathol. 2010;176(5):2385–93. doi:10.2353/ajpath.2010.090957. Arti...
3What Causes Dermatitis & Eczema? The common underlying feature of all types of dermatitis isdysfunction of the skin barrier. This is why topical therapies are important in managing symptoms. In a vicious cycle of impairment, the breakdown of healthy skin function can lead to immune system hypera...
The purpose of this review was to highlight the importance of the skin barrier in the development of atopic dermatitis (AD). Skin barrier function relies o
Flaky tail mouse de- notes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract. Am J Pathol 2010;176:2385-93. 81. Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, El...
Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes ...
AD, atopic dermatitis; AU, arbitrary unit; LDH, lactate dehydrogenase; NA, nonatopic. Serum total IgE and peripheral blood eosinophil counts were also significantly elevated in AD S. aureus+ participants compared with both AD S. aureus– and NA S. aureus– participants (Figure 2b and c). ...
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a complex, heterogeneous pathogenesis including skin barrier dysfunction, immunology, and pruritus. Although epidermal growth factor (EGF) is essential for epithelial homeostasis and wound healing, the effect of EGF on AD rema...
Conventional atopic diseases such as asthma, rhinitis, atopic dermatitis, and food allergies are prevalent in the marked populations, involving financial and medical resources, impacting the quality of life, frequently persisting after allergen tolerance breakdown in a typical manner. The recurrences ...
Atopic dermatitis (AD) is the most common inflammatory skin disease with no well-delineated cause or effective cure. Here we show that the p53 family member p63, specifically the ΔNp63, isoform has a key role in driving keratinocyte activation in AD. We find that overexpression of ΔNp63 ...