Impaired skin barrier is one of the hallmarks of atopic dermatitis (AD), with abnormalities in the cornified envelope, lipid lamellae, tight junctions and cutaneous microbiome. These findings are also present in nonlesional skin of AD individuals, suggesting that epidermal barrier defects may ...
IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction? J Invest Dermatol. 2011;131(1):150–7. https://doi.org/10.1038/jid.2010.277. Article CAS PubMed Google Scholar Nygaard U, van den Bogaard EH, Niehues H, Hvid M, Deleuran M, Johansen C, et...
Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. J Allergy Clin Immunol. 2015;135(4):930–5. 13. Kelleher MM, Dunn-Galvin A, Gray C, Murray DM, Kiely M, Kenny L, McLean WH, Irvine AD, ...
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressiv...
“outside-in” hypothesis, epidermal barrier dysfunction triggers immune activation; in contrast, based on the “inside-out” hypothesis, AD is primarily cytokine driven with secondary skin barrier dysfunction [14]. The modern approach to defining AD pathogenesis is now centered on integrating these...
Narrative systematic review of 21 studies (animal, lab and cohort studies) evaluating airborne pollutants, including traffic-related, particulate, volatile organic compounds (VOCs) and cigarette smoke on inducing skin barrier dysfunction and increasing atopic dermatitis can be found in Br J Dermatol 2020...
et al. Keratinocytes: innate immune cells in atopic dermatitis. Clin. Exp. Immunol. 204, 296–309 (2021). CAS PubMed Google Scholar Han, H., Roan, F. & Ziegler, S. F. The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol. Rev...
Factors involved in the development of atopic dermatitis include a weakened skin barrier, increased activity of immune cells in the skin, and the community of microorganisms (microbiome) living on the skin. Common Symptoms of Atopic Dermatitis Atopic dermatitis often affects certain areas of the bod...
Background Atopic dermatitis (AD) is a chronic dermatosis, predominant in childhood, characterized by pruritus and eczematous-type lesions with xerosis as the prominent clinical sign.Objectives To analyze the correlation between biophysical measurements of skin barrier function and other assessment criteria...
Unraveling the skin; a comprehensive review of atopic dermatitis, current understanding, and approaches pathological process behind atopic dermatitis is not fully known, it appears to be a combination of epidermal barrier dysfunction and immune dysregulation. Sk... M Afshari,M Kolackova,M Rosecka,....