Atopic Dermatitis Atopic dermatitisis a pruritic chronic inflammatory disease of the skin in which CD4+memory T lymphocytes, dendritic cell (DC) subsets, eosinophils, and mast cells infiltrate the perivascular, subepidermal, and intraepidermal areas. A number of chemokines are aberrantly expressed in ...
The role of AhR in transcriptional regulation of immune cell development and function. Biochim. Biophys. Acta Rev. Cancer 1873, 188335 (2020). CAS PubMed Google Scholar van den Bogaard, E. H. et al. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J. Clin. ...
and has severe impact on patients′ quality of life. Patients with moderate to severe atopic dermatitis often require systemic treatments, but traditional systemic treatments are ineffective or intolerable in some patients. In recent years, several biological agents ...
Core gene signatures of atopic dermatitis using public RNA-sequencing resources: Comparison of bulk vs. single-cell approachNext-generation sequencing, particularly RNA sequencing, has revolutionized dermatological research as a powerful tool to discover core pathologies. The primary RNA-sequencing approaches...
Atopic Dermatitis (AD) is a heterogeneous disorder with a wide spectrum of clinical signs, symptoms, severity and clinical course. Consequently, there is no single tool that comprehensively assesses all aspects of the disease. There are presently >60 measures that have been used to assess the sev...
Brandt, E. B. & Sivaprasad, U. Th2 cytokines and atopic dermatitis.J. Clin. Cell. Immunol.2, 110 (2011). ArticleGoogle Scholar Iking, A.et al.Prurigo as a symptom of atopic and non-atopic diseases: Aetiological survey in a consecutive cohort of 108 patients.J. Eur. Acad. Dermatol...
Recent findings on cytokines and specific cell types in atopic dogs are listed in Table 2. Table 2 Recent findings on T cells and cytokines in canine atopic dermatitis Full size table Skin barrier defects According to the “outside-in” theory an impaired epidermis leads to an increased ...
Design: A systematic review of articles published over a 13-year period was conducted to answer the following questions: (1) what information is given in the scientific literature concerning the use of probiotics in adult patients with atopic dermatitis? (2) Was there an improvement in the ...
Atopic dermatitis (AD) is a heterogenous disorder and can be classified into different types. Stratification of subtypes may enable personalized medicine approaches. AD can be categorized into the IgE-high, extrinsic subtype and the IgE-normal, intrinsic subtype. While extrinsic AD is the major subt...
AD, atopic dermatitis. Mouse Models of AD Mouse AD models can be categorized into three groups: (i) inbred strains of mice that develop AD-like phenotypes; (ii) genetically engineered models with either ablation or overexpression of a single gene, either ubiquitously or in a certain cell ...