The process of the present invention is an industrially useful and highly safe process for reducing sugar-moiety hydroxyl groups and halogen atoms in nucleic acids or derivatives thereof (including nucleic acid-related compounds) at low costs.Satoshi TakamatsuSatoshi KatayamaNaoko HiroseKunisuke IzawaUS
Similar trends are present in the same type of plot for the HA atom. In this case the helical values are at lower ppm while the β-sheet values occur at higher ppm. Interestingly, the average chemical shift value for HA atoms in a helix increases with higher ASA value (the helix data ...
Rigorous characterization of small organic molecules in terms of their structural and biological properties is vital to biomedical research. The three-dimensional structure of a molecule, its ‘photo ID’, is inefficient for searching and matching tasks.
Carbohydrates are a class of biological macromolecules that are used as a source of quick energy, but can also play a structural role in cell membranes and in nucleic acids. They consists of sugars and starches and are made of...
What atoms must be present in a molecule for it to be considered organic? Out of oxygen, carbon, hydrogen, nitrogen, calcium, phosphorus, potassium, sulfur, sodium, and magnesium, what elements are found in the four major biomolecules (carbohydrates, lipids,...
The compounds of the present invention may be prepared in the forms of pharmaceutically acceptable salts and solvates according to the known method in the related art.As the pharmaceutically acceptable salts, acid addition salts produced with free acids are preferred. The acid addition salts are ...
The Q linkages should be stable. The extent to which the spectrum of substituents present in the Q linkages can be extended can readily be determined by simple assays of stability of the resulting product, and this determination, and a good deal of predictability of the tolerance of these link...
nucleic acidscharge densityelectrostatic energyThe theoretical databank of aspherical pseudoatoms (UBDB) was recently extended with over 100 new atom types present in RNA, DNA and in some other molecules of great importance in biology and pharmacy. The atom-type definitions were modified and new ...
In proteins, -helices and 尾-sheets present the amino acid side chains on the surface while the polar amide bonds are buried. The opposite is found in double- and polystranded nucleic acids, where negatively charged phosphates occupy the surface and the side chains are hydrogen bonded in the ...
nucleic acidscharge densityelectrostatic energy.The theoretical databank of aspherical pseudoatoms (UBDB) was recently extended with over 100 new atom types present in RNA, DNA and in some other molecules of great importance in biology and pharmacy. The atom-type definitions were modified and new ...