Mechanobiology emerges at the crossroads of medicine, biology, biophysics and engineering and describes how the responses of proteins, cells, tissues and organs to mechanical cues contribute to development, differentiation, physiology and disease. The gr
Fig. 1. Fundamental principles of Atomic Force Microscopy (AFM) - based tissue mechanobiology. (A) Schematic describing the general AFM principles. An infrared laser is focused onto a soft microcantilever and its reflection is detected by a four quadrant photodetector. When the microcantilever is in...
Among the single‐cell analysis tools, atomic force microscopy (AFM) is a powerful and versatile one which is able to nondestructively image the fine topographies and quantitatively measure multiple mechanical properties of single living cancer cells in their native states under aqueous conditions with...
Over the past decade, atomic force microscopy (AFM) techniques have enabled substantial advances in our understanding of the tight relationship between force, mechanics and function in living cells and contributed to the growth of mechanobiology. In this Primer, we provide a comprehensive overview of...
Over the past decade, atomic force microscopy (AFM) techniques have enabled substantial advances in our understanding of the tight relationship between force, mechanics and function in living cells and contributed to the growth of mechanobiology. In this Primer, we provide a comprehensive overview of...
Atomic Force Microscopy in Mechanobiology: Measuring Microelastic Heterogeneity of Living Cells , ``Atomic force microscopy in mechanobi- ology: Measuring microelastic heterogeneity of living cells,'' in Atomic Force Microscopy in Biomedical Research... Evren,U.,Azeloglu,... - 《Methods Mol Biol》...
New Application Note: Introducing Scanning Capacitance Microscopy… Oxford Instruments Asylum Research Releases a New Application Note: Introducing… Read full article > Soft, Squishy and Sticky: AFM for Mechanobiology Webinar on Oct.… The AFM for Mechanobiology Webinar is an insightful overview of ato...
We review the advances obtained by using Atomic Force Microscopy (AFM)-based approaches in the field of cell/tissue mechanics and adhesion, comparing the solutions proposed and critically discussing them. AFM offers a wide range of detectable forces with a high force sensitivity, thus allo...
Atomic force microscopy has proven to be a valuable technique to characterize the mechanical and morphological properties of heterogeneous soft materials such as biological specimens in liquid environment. Here we propose a 3-step method in order to investigate biological specimens where heterogeneity hinde...
Mapping in vitro local material properties of intact and disrupted virions at high resolution using multi-harmonic atomic force microscopy. Nanoscale 5, 4729–4736 (2013). 15. Cartagena, A. & Raman, A. Local viscoelastic properties of live cells investigated using dynamic and quasi-static atomic...