Although the initial activation of protein kinase cascade is not fully understood,human protein kinases ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) are emerging as potential sensors of DNA damage. Current progresses in ATM/ATR research and related signaling pathways are ...
Other protein kinases related to ATM carry out similar functions in response to other genotoxic stresses, and some of them collaborate with ATM in the DSB response. ATM deficiency leads to ataxia-telangiectasia (A-T), a genomic instability syndrome, the hallmarks of which — neurodegeneration, ...
superfamilyofPhosphatidylinositol3-kinase-relatedkinases(PIKKs).ThePIKKsuperfamily comprisessixSer/Thr-proteinkinasesthatshowasequencesimilaritytophosphatidylinositol 3-kinases(PI3Ks).ThisproteinkinasefamilyincludesamongstothersATR(ATM-and RAD3-related),DNA-PKcs(DNA-dependentproteinkinasecatalyticsubunit)andmTOR (mam...
kinases (PIKKs). The PIKK superfamily comprises six Ser/Thr-protein kinases that show a sequence similarity to phosphatidylinositol 3-kinases (PI3Ks). This protein kinase family includes amongst others ATR (ATM- and RAD3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and ...
(PIKKs). The PIKK superfamily comprises six Ser/Thr-protein kinases that show a sequence similarity to phosphatidylinositol 3-kinases (PI3Ks). This protein kinase family includes amongst others ATR (ATM- and RAD3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and mTOR (...
ATM and ATR kinases phosphorylate KIFC1-S26 during DNA-damage conditions Next, we investigated the mechanism responsible for KIFC1 accumulation after DNA damage. The results showed that etoposide markedly delayed KIFC1 protein degradation (Fig.4a) without altering its transcription (Fig.4b). In addit...
Fig. 1. Schematic diagrams of the domain structure of phosphatidylinositol 3-kinase-related kinases (PIKKs). Known structural domains are shown for each protein. ATM (ataxia–telangiectasia mutated), ATR (ataxia–telangiectasia and Rad3 related), PRKDC (DNA-dependent protein kinase catalytic subunit...
ATM和ATR的信号传导通路综述 下载积分: 1500 内容提示: ATM ATM Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to...
ATR and DNA‑PKcs kinases— the lessons from the mouse models: inhibition ≠ deletion Demis Menolfi1* and Shan Zha1,2,3* Open Access Abstract DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates a complex...
8. Anika Maria Weber, Anderson Joseph Ryan. ATM and ATR as therapeutic targets in cancer[J]. Pharmacology & Therapeutics, 2015, 149. 9. Maréchal Alexandre, Zou Lee. DNA damage sensing by the ATM and ATR kinases[J]. Cold Spring Harbor perspectives in biology, 2013, 5(9). ...