Multi-modal single cell RNA assays capture RNA content as well as other data modalities, such as spatial cell position or the electrophysiological properties of cells. Compared to dedicated scRNA-seq assays however, they may unintentionally capture RNA f
Constructing such atlases becomes particularly challenging when working with highly heterogeneous datasets, such as whole-body images, which contain significant anatomical variations. Method In this work, we propose a pipeline for generating a standardised whole-body atlas for a highly heterogeneous ...
This study will provide a knowledge base which may be useful in improving the quality of map content of Korean geography textbooks and atlases.University of Pittsburgh.Paik, In Hee.University of Pittsburgh.
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing increasing depth and resolution to maps of huma...
Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support Similar content being viewed by others Single cell atlas of spinal cord injury in mice reveals a pro-regener...
of the reference map into “functional clusters” (Fig.1d), characterized by known gene expression signatures of specific T cell subtypes. We observed a distinct separation between CD4+and CD8+T cells, which could be further divided into subgroups. In particular, we identified a cluster of ...
However, the number of GPs may be very large, and potentially redundant, and not all are relevant for every atlas. To select only informative GPs, an attention-like mechanism is implemented with a group lasso regularization layer in latent space (Methods), which de-activates GPs that are redu...