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a, Collection and manual annotation processes of datasets with the DANIO-CODE DCC with highlights of key findings.b, Extent of the open repository for developmental multiomic data for zebrafish with assay type (yaxis) and developmental stage (xaxis). Data first reported in this study are highligh...
spanned by the first and third PCs is indicated on the x and y axis, respectively.eSample correlations. Hierarchical clustering of all sample types based on their RNA expression profiles. Off-diagonal entries denote the Pearson correlation between the expression profiles of two different sample typ...
(k) Plots showing the protein abundance ratio of CNOT8 (Y-axis) and copy number status of CNOT7 (X-axis) in the CPTAC Lung Adenocarcinoma (LUAD) and Breast Cancer (BRCA) cohorts showing a significant upregulation of CNOT8 protein in tumors with CNOT7 copy number loss (shallow and ...
We validated the single-cell data with animal and cellular experiments. After staining with toluidine blue on kidney slices of DKD mice, it was observed that treatment with losartan restored scattered fragmented mitochondrial to elongated and well-organized tissue in tubular cells (Fig.7A). Consistent...
Moreover, a recent study has demonstrated that USP28 can directly interact with PPARα (Lys152) and exert a protective effect in DCM by regulating mitochondrial homeostasis through the PPARα-Mfn2 axis. In conclusion, we have revealed subpopulations of metabolic reprogramming cardiomyocytes, activated...
Anyway, the whole shebang is often referred to as the atlas-axis complex, and that’s the reconstructed setup for a babyApatosaurusin the photo above. In addition to making a dull-colored one for the mount, Kyle made this festive version for the vert paleo teaching collection. Why so poly...
Epidermal growth factor-like protein 7 (Egfl7), an antagonist of Notch signaling (Schmidt et al., 2009), was also enriched in cluster 3, indicating that the Notch-VEGFR axis may differentially modulate angiogenesis across various fibrosis stages. The increase in Egfl7 at the late fibrosis ...
Figure 1. An olfactory-ethological atlas and the primary axis of olfactory perception in mouse (A–D) Videos (A) were scored for 18 behavioral parameters, grouped in three broad categories: (B) valence, (C) stress, and (D) exploration. (E) A graphical display summarizing the combinatorial...
For embryonic (E14.5 embryos) and neonatal (1 day-old pups) samples (except for gonads), sex is not determined before tissue pooling due to small sample size. More details are listed in Table S3. All experiments performed in this study were approved by the Animal Ethics Committee of ...