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Scale bar shows percent of regulon activity. TF: terminal filament; GSC: germline stem cells; EC: escort cells; FSC: follicle stem cells; pFC: prefollicle cells; polar: polar cell; stalk: stalk cell; MB: main body follicle cells; St.: Stage; ant.: anterior; cent.: central; post.: ...
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism Cell, 180 (2020), pp. 568-584 View in ScopusGoogle Scholar Sestan and State, 2018 N. Sestan, M.W. State Lost in Translation: Traversing the Complex Path from Genomics to Thera...
A central question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes into ‘co-essential’ pathways, but this approach has been limited
[5,6]. In contrast to lower sections of the GI tract, descriptions of the cellular transcriptional landscape in the stomach are lacking, with this organ absent from large-scale single-cell sequencing (scRNAseq) initiatives, such as Tabula Sapiens [7] and the Human Cell Atlas [8]. Where ...
For example, increasing computing power means the spatial scale of climate simulations has shrunk to the point where their output can resolve complex cloud textures [55]. Unsupervised cloud classification can help in assessing whether models capture those textures correctly. More broadly, advances in ...
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code distributions between the genes upregulated in “fed” mites and those downregulated in “fed” mites. As expected more enzyme-coding genes were found in the “fed” mite population, however, these increases were most profound amongst the oxidoreductase (“starved”n = 9, “fed”n...
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Many groups have proposed CRC subtypes based on large-scale gene expression studies. The International Consortium published the consensus molecular subtypes (CMS), which classified CRC as CMS1 (MSI immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal) based on bulk transcriptomic ...