P381 DIRECT INVESTIGATION OF BIVALENT MANGANESE IN ATHEROSCLEROTIC PLAQUE BY MEANS OF HIGH-FREQUENCY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPYdoi:10.1016/s1567-5688(10)70448-7A. GalyavichG. MaminE. KovalevaS. OrlinskiiV. PutliaevM. Salakhov...
英文: Conclusion: Carotid atherosclerotic plaques contain a variable degree of inflammation which can be assessed in vivo by means of FDG and PET. 中文: 结论∶颈动脉动脉粥样硬化患者动脉粥样斑包含不同程度炎症,可以在活体内用FDG和PET来评定。更详细... ...
Evaluation of carotid arteries and plaques in this region by means of PW and color Doppler has been useful up to date to diagnose carotid disease and its degree of severity and define treatment strategies. However, some limitations due to plaque characteristics like length, tortuosity, heterogeneity...
Plaque-infiltrating T cells are enriched for a particular subset, CD4+CD28– T cells.5 Such CD4+CD28– T cells are proinflammatory lymphocytes, which produce high amounts of interferon (IFN)-6 and tumor necrosis factor (TNF)-.7 They also are efficient killer cells, expressing perforin and gr...
Its main components are the necrotic cholesteryl ester rich core from which the disease process gets part of its name (the Greek stem "athero" means gruel or porridge) and the fibrous (sclerotic) cap which contains predominantly smooth muscle cells which often become encased in their own ...
These techniques provide new methods to assess the burden of atherosclerosis, gauge the risk of cardiovascular events, and offer a means to test the efficacy of therapeutic approaches to atherosclerosis. Furthermore, noninvasive coronary angiography can be performed with some of the new imaging ...
In a subsequent study, also in apoE-KO mice (N ¼ 36) with advanced atherosclerosis, we determined the mRNA expression levels of genes related to inflammation in plaque MFs by means of laser capture microdissection (LCM). We compared mice treated with high-dose [S]-rHDL with mice treated...
As plaque builds up in the arteries of a person with atherosclerosis, the inside of the arteries begins to narrow, which decreases or even blocks the flow of blood. Plaque can also rupture (break open). When it does, a blood clot can form on the plaque, blocking the flow of...
"At this point, we were able to see that signals coming from the plaque, once they reach the brain, influence the autonomic nervous system through the vagus nerve down to the spleen. Here, specific immune cells are activated and enter the blood circulation, leading ...
If this assumption is correct it means that patients with established disease with time will get insuffient protection by current therapies alone. Against this background it is critical to reach a better understanding of alternative mechanisms for plaque vulnerability. Examples of such mechanisms ...