As Fig. 1A shows, atherosclerotic lesions (white areas) were present in the aorta—predominantly in the aortic arch; in the origins of the brachiocephalic, left subclavian, and left common carotid arteries; and throughout the thoracic and abdominal aorta. After the gross anatomical examination,...
Lesions extended to the thoracic aorta at six months and the abdominal aorta at nine months [66]. Moreover, plaques formed in LDL−/− mice are representative only of the I–III phases, consisting predominantly of macrophage foam cells, while advanced lesions develop solely after prolonged ...