Thus, HDL-cholesterol levels and susceptibility to atherosclerosis appear to be determined by the same gene (or by two closely linked genetic factors that ... B Paigen,D Mitchell,K Reue,... - 《Proceedings of the National Academy of Sciences of the United States of America》 ...
Cellular and subcellular information exists on what can occur, but because the same lesions are not re-examined, what actually does occur is unknown. Studies of isolated arterial cell systems and intact lesions indicate that atherogenesis involves at least the following: Increased permeability of the...
the power to turn wonderful ideas into reality. Also to be noted is his role as a great inspirer and tutor of a large group of researchers, among whom the authors of the present tribute article written on the occasion of his 60th birthday. While over the years Dr. Hansson has hi...
Expression of these genetic traits is highly individual and can be affected by environmental factors such as diet and exercise. By understanding the heterogeneity of CAD, it becomes clear that all patients cannot be optimally managed with the same therapeutic regimen. Whereas elevated low-density ...
Single-cell analysis enables the evaluation of drug efficacy by comparing changes in cell abundance and gene expression patterns before and after treatment in the same study subjects or different groups. For instance, in the case of desmosterol, an emerging immunomodulator for atherosclerosis lipid over...
The frequency ofNPPBrs198389 AA genotype was significantly higher in women with obstructive CAD (P = 0.014). The same association was not observed in males. With respect to atherosclerotic burden, an association was found between the AA genotype and average luminal narrowing in women (P = 0.005...
OBJECTIVES: The aim of this study was to investigate whether shift work is related to elevated risk of coronary artery disease (CAD) by determining the coronary artery calcium (CAC) score and the presence of coronary artery stenosis by using coronary artery CT angiography (CCTA). METHODS: In ...
This can lead to serious complications such as a heart attack or stroke.2 Atherosclerosis can occur anywhere in the body, but it is particularly dangerous when it affects the arteries that supply oxygenated blood to the heart muscle. This is called coronary artery disease (CAD), and is the...
Here, we review the complex interplay between inflammatory, endothelial, smooth muscle and foam cells. Moreover, the putative role of inflammation in atherosclerotic CAD, underlying mechanisms and potential therapeutic implications are also discussed herein. Graphical abstract Download: Download high-res ...
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–prote