Atherosclerosis is the major cause of ischemic coronary heart diseases and characterized by the infiltration of cholesterol-accumulating macrophages in the vascular wall. Although sphingolipids are implicated in atherosclerosis as both membrane components and lipid mediators, the precise role of sphingolipids...
Atherosclerotic lesions represent a series of highly specific cellular and molecular responses that can best be described as an inflammatory disease. One possible mediator of inflammation is myeloperoxidase (MPO), a heme protein secreted form activated neutrophils, monocytes and some populations of macropha...
further basic research is necessary to understand more about the underlying functional mechanisms of the NPs. Other therapeutic strategies and current clinical trials targeting the NLRP3 inflammasome for atherosclerosis treatment would be described in the Atherosclerosis...
Rabbits were ™anaesthetized as described above, and a 50 µL contrast bolus was injected through an ear vein, followed by 1 mL normal saline injection. An EUP-L74M non-linear probe (5~13 HZ) with real-time ultrasound imaging (MI 0.15) was performed to capture microbubble reflow ...
M.R.D., as an employee of Midwest Biomedical Research, is a consultant for NewAmsterdam Pharma. In addition, M.R.D., as an employee of Midwest Biomedical Research, reports the following companies contracted consulting and/or research with their institution and it received the consulting fees ...
Accumulation in uremic plasma of reactive carbonyl compounds (RCOs), constantly produced by the metabolism of carbohydrates, lipids, and amino acids, and best described as “carbonyl stress,” results in AGE and ALE formation. AGEs/ALEs such as pentosidine, CML, malondialdehydelysine, imidazolone, ...
Attenuation of the effect of nitric oxide accounts for the majority of what is described as endothelial dysfunction. This occurs in response to atherosclerosis or its risk factors. Much remains to be learned about the molecular and genetic pathophysiological mechanisms of endothelial cell abnormalities....
Submission of an article to Atherosclerosis implies that the work described has not been published previously, except in the form of an abstract or as part of a published lecture or academic thesis. Submission of an article therefore means: The article is not under consideration for publication el...
Stable markers of inflammation such as high sensitivity C-reactive protein are indirect and potentially useful measures of endothelial function for example.Attenuation of the effect of nitric oxide accounts for the majority of what is described as endothelial dysfunction. This occurs in response to ...
Modified and oxidized apolipoprotein B (apoB) and cholesterol could also be implicated [17] although putative mechanisms are not as well described as for PC-exposing epitopes. While much evidence from epidemiological studies indicates that smoking is associated with atherosclerosis and CVD [18,19], ...