(2010). Atg8-family interacting motif crucial for selective autophagy . FEBS Lett. 584 : 1379–1385 [ PubMed ]Noda N. N., Ohsumi Y., Inagaki F. 2010. Atg8-family interacting motif crucial for selective autophagy . FEBS Lett. 584 : 1379Noda NN, Ohsumi Y, Inagaki F (2010) Atg8-...
Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H, Ohsumi Y: Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes. FEBS Lett 2015, 589:744-749.
Figure 3. TEX264 Associates with Specific ATG8 Family Members and Is Targeted for Autophagy through a C-Terminal LIR Motif (A) Domain structure of TEX264 showing the transmembrane segment, the GyrI-like domain, and the position of 2 candidate LIR motifs. The sequences on individual LIR motifs...
(2010). Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm- to-vacuole targeting pathway. J. Biol. Chem. 285, 29599-29607.M. Yamaguchi, N.N. Noda, H. Nakatogawa, H. Kumeta, Y. Ohsumi, F. Inagaki...
Here, we used yeast two-hybrid screening, and we identified transcription factor Deformed wings (Dwg) as an Atg8a-interacting protein in Drosophila. Dwg-Atg8a interaction is LIR motif-dependent. We have created Dwg Y129A/I132A LIR mutant flies and shown that they exhibit elevated autophagy,...
LIR motifautophagytranscription factorsLC3 (microtubule-associated protein 1 light chain 3, called Atg8 in yeast and Drosophila) is one of the most well-studied autophagy-related proteins. LC3 controls the selectivity of autophagic degradation by interacting with LIR (LC3-interacting region) motifs ...
Atg8 family interacting motif (AIMcanonical/non-canonical AIMsadaptor proteinsphosphorylation mediated regulationAutophagy mediates the selective degradation of various targets, such as aggregated proteins, damaged or superfluous organelles, and invading microbes. Specific adaptors, also known as receptors, ...
J. Roach, "Starch-binding domain- containing protein 1 (Stbd1) and glycogen metabolism: iden- tification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1," Biochemical and Biophysical Research Communications, vol. 413, no. 3, pp. 420- 425...
Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H, Ohsumi Y: Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes. FEBS Lett 2015, 589:744-749.
Establishing the hATG8 binding selectivity of AIM (autophagy-interacting motif) sequences found within autophagy system proteins provides insights into their biological roles, and in the case of disease-associated AIM mutations, potential pathophysiological mechanisms. Given the sometimes small differences ...