NRF2通过结合其靶启动子中的抗氧化反应元件(ARE)来激活抗氧化反应,而ATF4通过结合氨基酸反应元件(AARE)来控制氨基酸代谢。先前在癌细胞中的研究显示NRF2和ATF4靶基因之间存在一些重叠,包括CHOP/Ddit3和HO1。SLC7A11启动子含有一个ARE和...
[19]WEI W,LI Y,WANG C,et al.Diterpenoid vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells[J].Pharmacol Res,2022:106285. [20]Liu LF,Liu TY,Tao WW,et al.Flavonoids from Scutellaria barbata D.Don ...
与成骨细胞中的FoxO1合作,通过抑制β细胞生成和减少胰岛素生成来调节葡萄糖稳态。在HTLV-I的长末端重复序列中与一个税收反应增强因子结合,调节DDIT3/CHOP和天冬酰胺合成酶(ASN)对ER应激的诱导。与ddit3/CHOP协同,通过调节bbc3/puma的转录诱导,激活trib3的转录并促进ER应激诱导的神经元凋亡。激活siRT4的转录。...
DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells 2016; 34(1): 233-245.Roidl D, Hellbach N, Bovio PP, Villarreal A, Heidrich S, Nestel S, Gru€ning BA, Boenisch U, Vogel T. DOT1L ...
In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin ...
In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin ...
In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin ...
Atf4 and known downstream targets such as Atf3, Ddit3 (Chop), and fibroblast growth factor 21 (Fgf21) were also upregulated in Thbs1 DTG hearts compared with controls (Fig. 4f–i). Such results are interesting given that ATF4 and its downstream effector Fgf21 mediate atrophic remodeling in...
We found that Panc1 cells treated with tomatidine resulted in an increase in ATF4 and genes it is known to heterodimerize with and/affect transcription of, including CEBPβ, GADD45A, eIF4EBP1, ASNS, and DDIT3 (CHOP). Further, CHAC1, SLC3A2, and SLC1A5 that serve as connection to ...
36 Previous studies in cancer cells showed some overlap between NRF2 and ATF4 target genes, including CHOP/Ddit347,48 and HO1.49 The Slc7a11 promoter contains one ARE and two AAREs.50,51 To understand how ATF4 and NRF2 regulate SLC7A11 expression in non-transformed hepatocytes, we ...