Accelerated functional decay in ATF6-deficient hMSCs To explore the relationship between protein quality control and human stem cell aging, we checked the expression of a series of UPR proteins in replicative senescent hMSCs and premature aging (Werner Syndrome, WRN-deficient) hMSCs27,28,29,30(Supp...
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The cumulative distribution demonstrates about 25% upstream, 35% near the TSS, and 40% downstream, presumably in the gene body (Supplementary Figure S1E). As the CARE site has base pair variability at the 3’ end of the motif (XAAX), we examined whether any of the possible base pair ...
RNA-seq and transcriptome analyses were completed by the University of Rochester Genomics Research Center (URGRC). This work was supported by the Andrew McDonough B+ (Be Positive) Foundation’s Childhood Cancer Research Award (X.-G.L.), the Children’s Cancer Research Fund’s Emerging ...
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(48,403) Gross profit Other income and gains Selling and distribution expenses Administrative expenses Research and development costs Impairment losses on financial and contract assets, net Other expenses 260,358 22,267 (62,174) (58,732) (25,577) (635) (7,588) 193,516 7,789 (37,249) (...