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and its expression is rapidly induced by a wide range of cellular stresses, including DNA damage, oxidative stress, and cell injury [13]. ATF3 contains a basic-region leucine-zipper (bZIP) domain that binds to the ATF/CREBcis-regulatory element or the AP-1 element [14],...
Generation of stable cell lines. We generated stable subclones of expressing miR-424 by transducing the HEK 293T cells with lentivirus made using control and miR-424 expression vector pLenti-III-Tet-mir (Applied Biological Materials Inc) and puromycin selection (3 μ g/ml) for 7 days...
However, small molecules, as regulators of transcription factors, have been an understudied topic of chemical biology, mainly due to fear of non-selectivity or lack of efficaciousness when interfering with transcriptional regulation [127]. Furthermore, targeting one of the three primary effectors of ...
(274) Operating profits Finance costs 127,919 (5,641) 93,292 (7,948) Profit before tax Income tax expense 122,278 (1,380) 85,344 (4,729) Profit and total comprehensive income for the year 120,898 80,615 Attributable to: Owners of the parent Non-controlling interests 120,898 0 80,...