Mitochondrial function, including intracellular ATP content (Figure 1K) and the mitochondrial complex I and III activity (Figure 1L), both decreased after elesclomol–CuCl2 incubation. These results indicated that mitochondrial function plays an important role in the copper-induced cell death of ...
Mechanistically, ATF6 was shown to induce genes encoding proteins required for secretory granule exocytosis, including the t-SNARE, Snap23 [123,124]. Ectopic expression of Snap23 in the setting of ATF6 loss-of-function restored regulated ANP secretion, while Snap23 knockdown in culture and in ...