Atezolizumab /贝伐珠单抗 Bevacizumab用于晚期或不可切除的HCC 欧盟委员会已批准将atezolizumab(Tecentriq)加上bevacizumab(Avastin)的组合用于尚未接受过全身治疗的晚期或不可切除肝细胞癌(HCC)的成年患者。 据罗氏公司称,获得这一批准后,阿泰珠单抗/贝伐单抗是欧洲第一个获得批准的不可切除肝癌患者的免疫疗法。 该决定基...
德国协会肝病研究学会的Peter R.加勒,医学博士,医学部的大学医学中心的美因茨导演,并当选总统,讨论了从第三阶段IMbrave 150临床试验,评估出来的结果Atezolizumab(Tecentriq)加上bevacizumab(Avastin)与标准治疗方法索拉非尼(Nexavar)的组合作为不可切除的肝细胞癌(HCC)患者的一线治疗。 加勒说,每个周期都要对患者进行分析,...
The combination of atezolizumab (Tecentriq) and bevacizumab (Avastin) continued to display improved survival compared with sorafenib (Nexavar) in previously untreated patients with advanced hepatocellular carcinoma (HCC), according to updated findings from the phase 3 IMbrave150 trial that were presented d...
Because the combination of atezolizumab (Tecentriq) and bevacizumab (Avastin) has demonstrated superiority over sorafenib (Nexavar), it has become the new standard in the frontline treatment of patients with unresectable hepatocellular carcinoma (HCC), according to Joseph Kim, MD. Due to this success,...
TPS584#Background:The combination of atezolizumab and bevacizumab (AB) is an effective regimen for patients with advanced HCC1. Moving effective systemic therapy to earlier stages of HCC is a priority in improving outcomes. Assessing the safety of the combination of AB and TACE is essential to ...
EP: 2.Atezolizumab/Bevacizumab Benefit Potentially Extends to Child-Pugh B HCCStacey Stein, MD, associate professor of internal medicine at the Yale School of Medicine and assistant medical director of the clinical trials office at Yale Cancer Center, discusses the patient population and outcomes of...
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of TPST-1120 in Combination With Atezolizumab Plus Bevacizumab Compared With Placebo Plus Atezolizumab Plus Bevacizumab in Patients With Unresectable or Metastatic Hepatocellular Carcinoma (HCC) Not Previously Treated With Systemic Therapy ...
Atezolizumab plus bevacizumab (A+B) as first-line systemic therapy for advanced hepatocellular carcinoma (HCC): A multi-institution analysis of patient out... Atezolizumab plus bevacizumab (A+B) as first-line systemic therapy for advanced hepatocellular carcinoma (HCC): A multi-institution analysis ...
根据IMbrave150期研究(NCT03434379),在肝细胞癌(HCC)患者中,与索拉非尼相比,阿索唑单抗和贝伐单抗的一线组合在统计学上和临床上均改善了无进展生存期(PFS)和总体生存期(OS)来自罗氏。 使用atezolizumab / bevacizumab可使HCC患者的死亡风险降低42%(HR,0.58; 95%CI,0.42-0.79; P = 0.0006),PFS率为41%(HR,0.59...
The European Commission has approved the combination of atezolizumab (Tecentriq) plus bevacizumab (Avastin) for use in adult patients with advanced or unresectable hepatocellular carcinoma (HCC) who have not been given previous systemic therapy.1 With this approval, atezolizumab/bevacizumab is the first...