Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons. Eur J Pain. 2013;17(7):1012-1026.Anand U, Facer P, Yiangou Y, Sinisi M, Fox M, McCarthy T, Bountra C, Korchev YE, ...
Finally, application of AT2R antagonist decreased the renal ability of K excretion and caused hyperkalemia in wild-type but not in kidney-specific Kir4.1 knockout mice. We conclude that AT2R-dependent regulation of NCC requires Kir4.1 in the distal convoluted tubule and that AT2R plays a ...
Olodanrigan sodium (EMA-401 sodium) is an orally active and selective angiotensin II type 2 receptor (AT2R) antagonist, which can be used in research on neurological diseases. 别名 奥洛立更盐酸盐, PD-126055 sodium, PD126055 sodium, EMA-401 sodium, EMA401 sodium 化学信息 分子量 529.56 分...
Further Analyses of the Role of the AT2R in TAC-Induced Aortic Remodeling We sought to further characterize the role of AT2R in TAC-induced aortic remodeling. Because the nonpeptide-specific AT2R antagonist, PD123319,...
(AT2Rantagonist).valsartan(ATIRantagonist),PD98059(ERK1an—tagonist)andvalsartan+PD98059groups,andthelatter4groupsweretreatedwithvariousreceptorantagonistsbeforeandafterestablishmentofballoon—injuredaortamode1.Allratsweresacrificed7daysafteraortalinjury.andexpressionofAT1R,AT2RandERK1wasdeterminedbyRT—PCRand...
(Fig.2dand Supplementary Fig.S2c). Because the nonpeptide-specific AT2R antagonist PD123319 effectively prevents AT2R signaling in an aortic disease mouse model, mice were treated with both AT1-AA and PD123319. The results showed that PD123319 attenuated the harmful effects of AT1-AA on ...
(R)-CPP是一种 NMDA 受体拮抗剂 (Ki = 0.14 µM)。对含有 GluN2A(正式为 NR2A)的受体显示出一定的选择性(Ki 值分别为 0.041、0.27、0.63 和 1.99 μM,用于抑制含有 GluN2A、GluN2B、GluN2C 和 GluN2D 的重组 NMDA 受体)。 图1.(R)-CPP化学结构 ...
查看相关系列 GPCR/G Protein (3176) Neuronal Signaling (3340) Opioid Receptor (111) κ receptor Antagonist (19) 所有研究领域 Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 英文别名 UNII-3C6FZ6UXC8 | NCGC00378654-01 | Q909405 | (3R)-7-...
Circulating concentrations of tumor necrosis factor-a (TNF), interleukin (IL)-l尾, IL-6, IL-1 receptor antagonist (IL-lra), and soluble TNF receptors p55 (... van Deuren Marcel,van der Ven Jongekrijg Johanna,PNM Demacker,... - 《Journal of Infectious Diseases》 被引量: 319发表: 1994...
Circulating concentrations of tumor necrosis factor-a (TNF), interleukin (IL)-l尾, IL-6, IL-1 receptor antagonist (IL-lra), and soluble TNF receptors p55 (... van Deuren Marcel,van der Ven Jongekrijg Johanna,PNM Demacker,... - 《Journal of Infectious Diseases》 被引量: 319发表: 1994...