这项研究还表明,AT2受体缺乏可以显著减弱AT1受体阻滞剂(Angiotensin Receptor Blockers, ARBs)治疗引起的神经保护作用。此外,随后的研究表明,ARBs提供的神经保护作用受到AT2受体拮抗剂的抑制[29-30]。在这些研究之后,多项研究现已证明AT2受体激动剂在缺血性中风中产生有益作用[31],而其作用机制是多模式的,包括保护...
AT1 blocker candesartan versus ACE blocker enalapril in an experimental heart transplant model. J Heart Lung Transplant 2001; 20: 1092–1098.Richter M,Richter H,Skupin M,et al.Do vascular compartments differ in the development of chronic rejection?AT(1) blocker candesartan versus ACE blocker ...
AT2受体可以在缺血性中风中发挥保护作用的第一个直接迹象来自于研究,该研究表明,与野生型(Agtr2+)小鼠相比,AT2受体缺陷小鼠(Agtr2-)在永久性大脑中动脉闭塞后表现出明显更大的脑梗死和神经功能缺陷[28]。这项研究还表明,AT2受体缺乏可以显著减弱AT1受体阻滞剂(Angiotensin Receptor Blockers, ARBs)治疗引起的神经保护...
(e) cAMP concentration in response to vehicle, 0.3 µg/mL HMGB1, 100 µg/mL AGE-BSA, or 10–10 M angiotensin II in CHO-RAGE-AT1 pre-treated with vehicle, 10 µM losartan (AT1 blocker), or 10 µM FPS-ZM1 (RAGE inhibitor) (n = 8, each). *p < 0.01 vs. ...
To provide novel insights into the pathogenesis of heart failure-induced renal dysfunction, we compared the effects of ACE inhibitor (ACEi) and AT1 receptor blocker (ARB) on systemic and kidney hemodynamics during heart failure in normotensive HanSD and
Our results demonstrate that systemic administration of the centrally acting angiotensin II AT1 receptor blocker (ARB) candesartan to normotensive rats decreases the acute brain inflammatory response to administration of the bacterial endotoxin lipopolysaccharide (LPS), a model of brain inflammation. The ...
a2012 Германия 2012年Germanies[translate] awhereas the AT1 receptor blocker can prevent the generation of ERK, and thereby the activation of c-fos proteins, and JNK 而AT1感受器官预锻模可能防止ERK的世代和从而cfos蛋白质和JNK的活化作用[translate]...
临床上,血管紧张素转化酶抑制剂(angiotensin converting enzyme inhibitor,ACEI),血管紧张素受体阻断剂(angtiotensinreceptor blocker,ARB)已成为治疗和延缓糖尿病肾脏损害的一线药物.然而,实验室研究及临床观察结果均显示,即使大剂量ACEI或ARB只能延缓但不能... 陆利民 - 中国生理学会全国会员代表大会暨生理学学术大会 被...
and urinary protein loss using angiotensin-converting enzyme inhibitors and AT1 blockers, statins, dietary counseling for a low-sodium and low-protein diet ... F Eitner,D Ackermann,RD Hilgers,... - 《Journal of Nephrology》 被引量: 103发表: 2008年 The A1166C polymorphism of the AT1 recept...