Cancer stem cells, in particular, undergo asymmetric division, leading to intra-tumoral heterogeneity, which contributes to treatment refractoriness. In this review, we delve into the cellular and molecular mechanisms that govern asymmetric division and explore its relevance to tumor...
Stem cells have the remarkable ability to self-renew, meaning that upon asymmetric divisions they generate one daughter endowed with the same stem-like property of the mother, and another one prone to differentiate. Asymmetric cell divisions (ACDs in the following) are attained by unequal segregati...
Germline stem cells In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the ... A Spradling,MT Fuller,RE Braun,.....
Asymmetric division of stem cells is an evolutionarily conserved process in multicellular organisms responsible for maintaining cellular fate diversity. Symmetric-asymmetric division pattern of mesenchymal stem cells (MSCs) is regulated by both biochemical and biophysical cues. However, modulation of mechanotra...
Asymmetric divisions maintain long-term stem cell populations while producing new cells that proliferate and then differentiate. Recent reports in animal systems show that divisions of stem cells can be uncoupled from their progeny differentiation, and the outcome of a division could be influenced by ...
Frank.Hirth@iop.kcl.ac.ukofhumantumorstoo.Indeed,cancerstemcellshavealreadybeenidentifiedinleukemia,andinsolidtumorsofthebreastandbrain.Inaddition,inappropriateactivationofpathwayspromotingtheself-renewalofsomaticstemcellsincludingdefectsinasymmetriccelldivisionhasbeenshowntocauseneoplasticproliferationandcancerformation....
Listen to an interview with Sean Morrison on the stem cells podcast Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generat
Cell adhesion in regulation of asymmetric stem cell division Adult stem cells inevitably communicate with their cellular neighbors within the tissues they sustain. Indeed, such communication, particularly with compon... YM Yamashita - 《Current Opinion in Cell Biology》 被引量: 77发表: 2010年 Control...
1) asymmetric division 非对称性分裂 1. The significant characteristic of stem cells isasymmetric divisionto achieve self-renewal. 干细胞最大的特点是非对称性分裂从而实现自我更新,如果这一过程被扰乱则会发生肿瘤。 2) asymmetry 非对称 1. Asymmetry of the Contract, Hiring and Enterprise Ownership; ...
FaubertA,Lessard J,Sauvageau G.Are genetic determ inants of asymmetric stem cell division active in hematopoietic stem cells?. Oncegene . 2004Faubert A, Lessard J, Sauvageau G. Are genetic deter- minants of asymmetric stem cell division active in hemato- poietic stem cells? Oncogene. 2004;...