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Recently, ASXL2 mutations (ASXL2mut) were found with a high incidence (~23%) in a cohort of 110 pediatric or adult AML patients (pts) with t(8;21)(q22;q22) (Micol et al., Blood 2014). Aim: We assessed the frequency and prognostic impact of ASXL2mut in the context of other ...
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Ernst, P. et al. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev. Cell 6, 437–443 (2004). 2. Klauke, K. et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat. Cell Biol. 15, 353–362 (2013)....
D., Yu, P., Wang, Q. F., Xu, M., and Yang, F. C. (2017) Loss of Asxl2 leads to myeloid malignancies in mice. Nature communications 8, 15456Li J, He F, Zhang P, et al. Loss of Asxl2 leads to myeloid malignancies in mice. Nat Commun. 2017;8:15456....
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