It is important to note that in both nonreactive and reactive astrocytes, the expression of GFAP protein that can be detected by immunohistochemistry (IHC) is limited to the proximal portions of cell processes which means that the complexity of the fine distal processes and their associated volume...
The literature-derived CBN model backbone was expanded using a data-driven approach to identify additional molecular drives in astrogliosis that might have been missed during literature curation. The approach utilized a database of nearly 800 nodes with inferable activities (iNodes). The activity of t...
To inquire into the role of commonly upregulated DEGs across HD brains, we analyzed them by means of the STRING v11.5 tool. The analysis generated a gene/protein interaction network (Fig. 1; strength of interaction score > 0.7) consisting of 217 DEGs (nodes) and 99 edges. Nodes ...
Data are reported as means ± S.E.M. of 8–10 animals and expressed as percent of control. Statistically significant differences from canola oil-treated rats, as determined by one way ANOVA followed by Tukey–Kramer test are indicated: *P < 0.05. Next, we examined the involvement of MAPKs...
Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35鈥 55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated \\\{CNS\\\} inflammatory/demyelinative disorder that...
Objective We evaluated the relationship between reactive astrogliosis and delayed motor neuron death after transient spinal cord ischemia in rabbits using a semiquantitative analysis of glial fibrillary acidic protein expression. Methods Spinal cord ischemia was induced by means of balloon occlusion of the...
Data are presented as means ± SEM (n=5‐10). Male data were compared by Student's t‐test and female data were compared by one‐way ANOVA unless otherwise stated. Systolic blood pressure was elevated in AngII‐treated male mice (sham: 133 ± 10, AngII: 181 ± 1...
That \\{CR\\} affects levels of \\{GFAP\\} expression but not amyloid plaque load provides some insight into the means by which \\{CR\\} is beneficial at the microstructural level, potentially by offsetting the increased load of oxidatively damaged proteins, in this non-human primate model...
Tempera- ture changes were expressed as means 卤 S.E.M. from three sepa- rate measurements and statistical significance was calculated using Students' t-test.Albert Cheung Hoi YuBing Yi WuRong Yu LiuQiang LiYue Xin Li
In a follow-up study, we analysed plaque load, the activation of astrocytes as a means of chronic inflammation in the brain, and oxidative stress in the brains of these mice (8-oxoguanine levels). D-Ala2GIP reduced the amyloid plaque load in 12- and 19-month-old mice, and the ...