The 5-year progression-free survival rate was 77% and 50% respectively (p=0.013). For those patients in whom irradiation is deemed appropriate, some authors would recommend using stereotactically guided conformal techniques to minimize radiation exposure to normal surrounding brain structures (Saran ...
As shown in Table 1, the higher expression of CASC2c also markedly correlated with clinical stage and death of patients, but it is not correlated with gender and age. To further examine the effect of expression of CASC2c on the survival of astrocytoma patients, we employed the Kaplan– ...
Over expression of HNRNP K even in early stage, low grade tumors suggest the possible significance of alterations in these regulatory mechanisms as initial events. Interestingly, the localization of HNRNP K on the cell surface and their role in cell adhesion44 has also been been demonstrated. ...
Wellbrock C, Karasarides M, Marais R: The RAF proteins take centre stage. Nat Rev Mol Cell Biol 2004, 5: 875–885. 10.1038/nrm1498 Article CAS PubMed Google Scholar Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, ...
A 2-stage design was utilized, with 90% power to detect PFS6 increase from 25 to 45%.In the Phase I, maximum tolerated dose was not reached at 1200mg/D. For phase II patients, overall PFS6 was 33% and median PFS 4.0months (95% CI 2.1, 5.7). Median overall survival (OS) was ...
With the informed consent of all patients and approval of the ethics committee, the tumor samples were collected from astrocytoma patients (n = 53) during operation at the Tiantan Neurosurgical Hospital in Beijing. The pathological classification of tumor tissues was carried out and the stage of ea...
There were no age, sex, race, or tumor stage restrictions. Each new patient was screened with a brief eligibility questionnaire that assessed prior tumor therapy and willingness to participate in this study by the instituted staff interviewers. If the patient was willing to participate, the ...