Blood–brain barrierAstrocyteEndothelial cellsAstrocytic endfeetTight junctionsThe evolution of blood–brain barrier paralleled centralisation of the nervous system: emergence of neuronal masses required control over composition of the interstitial fluids. The barriers were initially created by glial cells, ...
The blood–brain barrier (BBB), which is formed by the endothelial cells that line cerebral microvessels, has an important role in maintaining a precisely regulated microenvironment for reliable neuronal signalling. There is great interest in the association of brain microvessels, astrocytes and neuron...
Astrocytes extend endfeet that enwrap the vasculature, and disruptions to this association which may occur in disease coincide with breaches in blood-brain barrier (BBB) integrity. Here we investigate if focal ablation of astrocytes is sufficient to disrupt the BBB in mice. Targeted two-photon chem...
but their main activity is the maintenance of the inner blood-retina barrier. In response toinjuryor disease, they are able to upregulate the expression of various genes encoding cytokines,chemokinesand elements of the complement cascade, compromising the integrity of the blood-retina barrier and pro...
The blood–brain barrier: an overview: Structure, regulation, and clinical implications - ScienceDirect Germinal matrixAstrocytePericyteThe blood–brain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds from blood to brain. Three ... P Ballabh,A Braun,M Nedergaard - 《...
It was also possible that the nm embryos had cerebrovascular abnormalities that might affect astrocytes whose end-feet surround the endothelial cells forming the blood–brain barrier. We imaged the brain circulatory system in E18 chick embryos by intra-cardiac injection of 100 μl of fluorescein–...
Astrocytes (also known collectively as astroglia) are characteristic star-shaped glial cells in the brain and spinal cord. They perform many functions, including biochemical support of endothelial cells which form the blood-brain barrier, provision of nutrients to the nervous tissue, maintenance of ...
note that LPS does not appreciably cross the blood-brain barrier (BBB)51. Rather, the brain effects and behavioral changes of peripheral LPS administration are thought to be induced by an influx of cytokines and infiltration of activated immune cells crossing into the brain to drive ...
blood brain barrier GA: gestational age GFAP: glial fibrillary acidic protein GM: germinal matrix TJ: tight junction WM: white matter References Ballabh P, Braun A, Nedergaard M 2004 The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 16...
DOI: 10.1203/01.pdr.0000214975.85311.9c Abbreviations: AQP4, aquaporin-4; BBB, blood brain barrier; GA, gesta- tional age; GFAP, glial fibrillary acidic protein; GM, germinal matrix; TJ, tight junction; WM, white matter 673 674 EL-KHOURY ET AL. cells (9). AQP4 expression is highly ...