The design scheme reflects the best of the design team’s knowledge and learnings from each end of the sector spectrum, and the bespoke design elements really speak to the aspiration. The Standard Hotel over the road was a constant reference point, sparking off conversations about possibilities ...
1. A process for preparing a compound of Formula (I), wherein R1 is defined as in Formula (I) and X is S and Y is O is shown in Scheme 1:Compounds of formula (II), (III), (IV), (V) and (VI) are useful intermediates in the preparation of compound of Formula (I) wherein...
The compounds of the formula (VII) may be prepared as shown in Scheme 1 below and by methods analogous to those described in the examples.Step 1: A compound in accordance with formula (X), wherein R1, R2, PG3 and PG4 are as previously defined, can be obtained by reacting a compound...
Scheme I): For compounds of formula (VI) where A is 0, and X is not carbon: The conversion of (VIB) to (VI) may also be achieved by reaction with Br—(CH2)n—CHO, or an equivalent ester, in DMF and the presence of a base, followed by reaction with a sulphur ylide such as...
Alternatively, compounds of Formula (Ma) where R1 represents difluoromethoxymethyl may be made according to Scheme 3 as shown below. wherein: R2, R3, A and n are as defined for Formula (I), P1 and P2 are suitable protecting groups, for example (1-4C)alkyl and TIPS respectively, and...
As shown in Scheme 4, amine V can then be transformed to an amide, a carbamate or an urea using standard organic chemistry procedures to give compounds of formula I. The reagents for these transformations such as, but not limited to, carboxylic acids, acid chlorides or anhydrides (R4CO2H,...
Reaction Scheme 2 may be generalised by the skilled man to apply to compounds within the present specification which are not specifically illustrated (for example to introduce a substituent other than methoxy at the 7-position in the quinazoline ring). Compounds of the Formula III are commercially...
For example, compounds of formula (IV) in which R1 represents a hydrogen atom, Y represents NH and Z1 and Z2 both represent oxygen may be prepared according to the reaction scheme below: Alternatively, compounds of formula (IV) in which R1 represents a hydrogen atom, Y represents NH, Z1...