In a 25 ml microwave vial, 1-allyl-3-(5-bromobenzo[d] thiazol-2-yl)urea (300 mg, 0.96 mmol, intermediate 5) in ethylene glycol dimethyl ether (5 mL) was taken, ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate (346 mg, 1.25 mmol), tetrakis (triphenylphosphine) ...
Microwave heating was achieved with a Personal Chemistry Smith Synthesizer or a Personal Chemistry Emrys Optimizer (monomodal, 2.45 GHz, 300 W max). Supercritical Fluid Chromatography (SFC) was performed as a means of purification for selected compounds and intermediates. Reverse Phase High Pressure Li...