ADAM 33 is the most studied candidate gene followed by IL4, IL13, and CD14. Candidate gene association studies can identify the risk alleles and provide a better picture of the genetic association of asthma. These studies may not have the ability to explore new genes, they still help to ...
In fact, asthma is now described as a risk factor for chronic obstructive pulmonary disease. Clearly, the pathogenic mechanisms have not been identified in this process, and thus research needs to target this very important topic. A combination of genetic and environmental factors is probably the ...
Be- cause allergic diseases, including asthma, rhinitis, and eczema, are caused by both environmental and genetic factors, the expression of allergic asthma is dependent on inheritance of local susceptibility genes, which have the potential to interact with the atopy predisposition, whereas nonallergic...
To experimentally test the candidacy ofin asthma susceptibility, we characterized five genetic variants of(5鈥睠A, 274C>T, 469+14G>C, D543N, and 1729+del4) in an asthma family-based cohort from northeastern Quebec. We did not observe any significant association betweenvariants (either allele...
Strong genetic and environmental drivers of asthma interconnect through novel epigenetic mechanisms that operate prenatally and throughout childhood. Asthma can spontaneously remit or begin de novo in adulthood, and the factors that lead to the emergence and regression of asthma, irrespective of age, ...
It is a predominant viral illness, in which the RSV (respiratory syncytial virus) is the agent in more that 50% of cases. It is not known how many children with genetic predisposition to atopy develop asthma symptoms after bronchiolitis, however the......
PURPOSE: IgE was identified by Ishizaka as an antibody that is reacted at Type I hypersensitivity reaction, and has been used in the diagnosis of allergic disease and the differential diagnosis of extrinsic and intrinsic asthma. But there was some confusing in the diagnosis because of the broad...
control for population ancestry, genetic correlation would occur only if the germline genetic variant is causal or in linkage disequilibrium (LD) with the causal variant of both traits. A purely environmental confounding factor (eg, air pollution) would not lead to genetic correlation because it is...
Asthma is a multifactorial disease influenced by genetic and environmental factors. Because of its complicated nature, asthma treatment is a very difficult and exhausting process. Asthma can be categorized based on either phenotype (i.e., functional and physiopathological), severity (intermittent, mild...
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