Improvements In Individual Asthma Control Questionnaire (ACQ-5) Questions With Reslizumab In Patients With Inadequately Controlled Asthma and Elevated Blood Eosinophils: Pooled Analysis of Two Phase 3 Trialsdoi:10.1016/j.jaci.2017.12.054Korenblat, Phillip E....
We ascertained asthma control with Asthma Control Questionnaire of five questions (ACQ-5), validated in Russian [8], which allowed to quantify asthma control using a numerical score ranging from 0 to 6. In addition, we also categorized patients into those with well controlled, partially controlled...
Asthma Control Questionnaire (ACQ) TheAsthma Control Questionnaire(ACQ) has also been validated.8The ACQ score has been shown to correlate with a measure of control based on the GINA/NIH criteria. This instrument includes six questions on symptoms, activity limitation and beta2-agonist use, with...
The primary endpoints of the study were the proportion of patients who experienced a loss of asthma control event during the study and a change from baseline in Asthma Control Questionnaire-5 (ACQ-5) scores. “Treatment with high and low dose oral rilzabrutinib led to a numerical (36% and...
Secondary outcomes included differential eosinophil counts in sputum and peripheral blood, asthma control questionnaire-5 (ACQ-5) and concomitant use of medication. Pooled SMDs (standardized mean differences) were estimated by using a random-effect model and a fixed-effect model based on between-...
Primary outcomes were the slopes of plots of Asthma Control Questionnaire (ACQ) scores versus time following randomization; and the percent change in percent predicted FEV1 (Delta FEV1% pred) from enrollment to the end of the study. Associations between SNPs and outcomes were analyzed using general...
In some of these studies, there were small differences in lung function (FEV1) and symptom control assessed by Asthma Control Questionnaire (ACQ-5) score that favored daily maintenance ICS over as-needed-only low-dose ICS–formoterol. These differences were not clinically important, and may ...
We set out to ascertain the sensitivity and specificity of the Juniper Asthma Control Questionnaire (ACQ) and/or the peripheral blood eosinophil count to detect a sputum eosinophil count >3%. Methods We performed a retrospective, cross-sectional study of 165 subjects with asthma, aged 18–80, ...
Results After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P<.001).The mean asthma quality‐of‐life ...
The Control of Allergic Rhinitis and Asthma Test (CARAT) questionnaire was created and validated to measure disease control of both asthma and allergic rhinitis.19,20 However, the minimal clinically important difference (MCID), a vital measure for the interpretation of CARAT scores,21 is unknown....