In the lung, exposure to allergens induces IgE-mediated mast cell degranulation. By this process, chemical mediators are released and attract inflammatory cells that infiltrate the airway wall. This immune response is a potent stimulus for the pathologic changes seen in asthma (e.g., bronchospasm,...
Asthma is a chronic inflammatory disease of the lung and its pathophysiology is initiated by mast cell activation in response to the antigen binding to IgE receptor as well as by TH2 cell activation. Mast cells are well established effector cells in asthma where they exacerbate the inflammatory ...
Many agents are capable of mast cell activation (MCA). In the lung, exposure to allergens induces IgE-mediated mast cell degranulation. By this process, chemical mediators are released and attract inflammatory cells that infiltrate the airway wall. This immune response is a potent stimulus for the...
Exercise, asthma, and mast cells. Lancet. 1983 Apr 9; 1 (8328):822–822.Howarth, P. H., and Holgate, S. F., 1983, Exercise, asthma, and mast cells, Lancet 1 :822 (abstr.).Howarth PH, Holgate ST. Exercise, asthma and mast cells [letter]. Lancet 1983;i:822....
As an important mediator of allergic inflammation, mast cell tryptase is involved in the induction of hypersensitivity, infiltration of inflammatory cells and tissue remodeling in respiratory tract. The effects of tryptase inhibitors on the actions of tryptase show further the potenti...
图书Bronchoalveolar Mast Cells and Asthma 介绍、书评、论坛及推荐
For people with asthma, an allergy attack can often feel like an asthma attack. Learn more about allergy-induced asthma and how it works.
The role of the mast cell in asthma: a reassessment. Interest in the role of the mast cell in bronchial asthma has waxed and waned over several decades, but there is now compelling evidence that mast cells ma... Peter,Bradding - 《Current Opinion in Allergy & Clinical Immunology》 被引量...
Pharmacological modulation of mast cell-mediated airway inflammation in asthma. Introduction: Splanchnic mast cells increase in chronic liver and in acute-on-chronic liver diseases. We administered Ketotifen, a mast cell stabilizer, an... K Ri 被引量: 0发表: 2004年 Mast-cell responses in the de...
REVIEWS The microbiology of asthma Michael R. Edwards1,2 Nathan W. Bartlett1 Tracy Hussell1 Peter Openshaw1 and Sebastian L. Johnston1 Abstract | Asthma remains an important human disease that is responsible for substantial worldwide morbidity and mortality. The causes of asthma are ...