AST-021p (100 渭g) plus TLR-2/3 agonist significantly improved immunogenicity by increasing HSP-90 epitope-specific T cells up to 130卤10 per 1x105 spleen cell of FVB/N mice (P<0.001). AST-021p plus TLR-2/3 agonist also showed higher tumor growth inhibitory effect (170卤108 mm3)...
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Four-dose cohorts of AST-021p (Cohort 1: 1.2mg, Cohort 2: 2.4mg, Cohort 3: 3.6mg, Cohort 4: 4.8mg) received three vaccinations at 2-week intervals (Priming immunization) followed by boosting immunization with 4-week interval based on PI's discretion. Enrolling one patient initially in ...