16.2 吸收 当连续 10 天重复口服给小鼠 C 标记的 Kremezin 时,未观察到体内吸收或积累。 16.5 排泄 当C 标记的 Kremezin 以单剂量口服给小鼠时,几乎全部量在 24 小时后通过粪便排泄。 17. 临床表现 17.1 疗效和安全性研究 17.1.1. 国内 III 期试验(一般临床试验) 在保守治疗期间的566例慢性肾功能衰竭患者中...
产地国家:日本处方药:是所属类别:2克/颗粒 84袋 包装规格:2克/颗粒 84袋 计价单位:盒生产厂家中文参考译名:吴羽化学 生产厂家英文名:Kureha 原产地英文商品名:AST-120 granules 2g 84sachets 原产地英文药品名:KREMEZIN 中文参考商品译名:AST-120 2克/颗粒 84袋 中文参考药品译名:克里美净 简介 部分中文AST...
碳素颗粒(1)AST-120[AST-120]凯美津克美司商标名kremezin kremose 200mg商品名kremezin granules2g保护肾脏的适应症适应症:口服2 gtid不同适应症及年龄组患者使用剂量的药理成分:每包2gm含直径0.2-0.4mm的黑色多孔球形炭颗粒;每个球形活性炭含有许多20-15000nm(纳米)的孔径1gm的总表面积相当于一个足球场的面积...
AST-120 ,商品名KREMEZIN,适应症:慢性肾病、终末期肾病,机制:利用活性炭强吸附作用减少机体对尿毒滞留物质等的吸收查了好久的文献,今天一搜发现居然早就上市了[允悲]厉害啊
AST-120 (Kremezin) is used to treat progressive chronic kidney disease (CKD) by adsorbing uremic toxin precursors produced by gut microbiota, such as indole and phenols. In this study, we propose that AST-120 reduces indole level, consequently suppresses indole effects on induction of drug ...
AST-120 (kremezin; Kureha Chemical, Tokyo, Japan) is an oral spherical carbonaceous adsorbent, which was approved for clinical use in Japanese chronic kidney disease (CKD) patients in 1991. It adsorbs indole, the precursor of indoxyl sulfate, in the intestines and prevents indoxyl sulfate product...
The oral adsorbent, AST 120 [Kremezin; Kureha Chemical], has been approved in South Korea
Adsorption of irinotecan onto oral adsorbent AST-120 (Kremezin) for preventing delayed diarrhea. Cancer Chemother Pharmacol 2007; 59:321-328. An important study on the use of an oral adsorbent to ameliorate irinotecan- induced diarrhoea.Hidaka M, Yamasaki K, Okumura M, et al: Adsorption of ...
NA;Inpharma weekly
AST-120 (KREMEZIN) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces. Uremic toxins such as indoxyl sulfate and p-cresyl sulfate are abundant in the blood of chronic kidney ...