The exploited pancreatic pre-neoplastic lesion organoid transplantion in syngeneic mouse model resulted a good approximation of human PDAC pathology, which develops slowly together with desmoplasia establishment [46, 56, 57]. Moreover, since at the time of diagnosis, 50% of patients presents ...
Under a Johns Hopkins Medical Institution Institutional Review Board approved protocol, FFPE blocks were obtained from the pathology archive and clinicopathologic information were obtained through chart review. Sequential IHC and image acquisition The sequential staining-striping multiplex IHC protocol has been...
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Republic of Korea Seok-Hyung Kim Contributions C.O.S.: Conceptualization. S.J.C. and C.O.S.: Analysis of the genomic and clinical data; interpretation and visualization of the results. J...
2014; Macario and Conway de Macario 2019, 2020) and in the dedicated continuously updated Web site The Chaperonopathies (http://www.chaperones-pathology.org). While the preceding considerations apply to the chaperoning system whose components are proteins with polypeptides-proteins as substrates, ...
Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China Siyi Wang Department of Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China Qingxin Xia Contributions N.L. and C.W. ...
et al. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat. Neurosci. 24, 1522–1533 (2021). Article CAS PubMed PubMed Central Google Scholar Ross, J. M. et al. The expanding cell diversity of the brain vasculature. ...
AD has quickly become a commonly used model to study A1-like astrocytes. Since their characterization, a variety of mechanisms by which A1-like astrocytes contribute to AD pathology have been described. The link between A1-like astrocytes and AD appears to begin at the genetic level. Among the...
and pathology and autopsy records (when available) to determine patients’ demographics, hospitalization characteristics, comorbidities, presence or absence of sepsis, and cause of death. Fixed categories of race/ethnicity, as reported by patients in the medical records of each hospital, were abstracted...
The CNS is the major target of ZIKV infection. In addition to the induction of massive neuronal cell damage, ZIKV-mediated neuroinflammation is the key to causing neurological pathology via an excessive inflammatory response, particularly in neonates. The relationship between ZIKV-induced neuroinflammation...
With respect to mGluR-3, some investigations indicate their neuroprotective effects [162]; thus, the hypothesis has emerged that enhancement of mGluR-3 signaling may provide pro-cognitive benefits in addition to ameliorating some of the neuroinflammatory pathology seen in schizophrenia [159,163]. Never...