1961. Assembly of the peptide chains of hemoglobin. Proc. Natl. Acad. Sci. U. S. A. 47:247-261.H. M. Dintzis. Assembly of the peptide chains of hemoglobin. Proceedings of the National Academy of Sciences of the United States of America, 47:247-261, 1961....
1. One step in the assembly of hemoglobin is the combination of heme with the globin peptide chains. The binding of heme to the peptide chains does not seem to occur while these are being synthesized. Polysomes obtained from rabbit reticulocytes labeled in vitro with 59Fe have been examined...
In sickle-cell disease, the symmetry of haemoglobin exacerbates the effect of a mutation, triggering assembly into harmful fibrils7. Here we examine the universality of this mechanism and its relation to protein structure geometry. We introduced point mutations solely designed to increase surface ...
In this work, we develop a peptide-ferriporphyrin conjugate with tumour microenvironment specific activation for improved tumor penetration and endocytosis, which enables effective inhibition of GPX4 due to the assembly enhanced binding (AEB) effect, ultimately improving its anticancer activity via ferroptos...
The EMC2 binding site was mapped to a previously uncharacterized C-terminal peptide that is predicted to form a conserved amphipathic α-helix (see Figure S4A). Polar residues are shown in blue and hydrophobic residues are shown in yellow. A mutational analysis (Figure S4C) revealed residues ...
The peptide chains may be reversibility and strength of the protein polymers generated upon arranged in an antiparallel fashion, connected by reverse turns, assembly. Indeed, microtubules and actin filaments are intrinsi- or in a parallel fashion. Antiparallel β-sheets exhibit a crystallo- cally ...
" Ordered Heme Binding Ensures the Assembly of Fully Functional Hemoglobin: A Hypothesis " Current Protein and Peptide Science 3 (pp. 461-466), 2002.Vasudevan G, McDonald MJ. Ordered heme binding ensures the assembly of fully functional hemoglobin: a hypothesis. Curr Protein Pept Sci. 2002; ...
J. Ordered Heme Binding Ensures the Assembly of Fully Functional Hemoglobin: A Hypothesis. Curr. Prot. Pept. Sci. 2002 , 3 , 461–466.Vasudevan et al. " Ordered Heme Binding Ensures the Assembly of Fully Functional Hemoglobin: A Hypothesis " Current Protein and Peptide Science 3 (pp. 461...
The next generation of nanowires that could advance the integration of functional nanosystems into synthetic applications from photocatalysis to optical devices need to demonstrate increased ability to promote electron transfer at their interfaces while
This could be explained by a lack of binding partners and targeting sequences to the Balbiani body for all three of these proteins: Hemoglobins need their cofactor, heme, for proper folding and function. Oocytes are rich in hemoglobins (Peshkin et al., 2015) and a lack of accessible ...