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The Arf6-specific exchange factor EFA6 is involved in the endocytic/recycling pathway for different cargos. In addition EFA6 acts as a powerful actin cytoskeleton organizer, a function required for its role in the establishment of the epithelial cell pol
Download: Download full-size image Figure 6. Activation of Arp2/3 complex away from the bead surface decreases steady-state soluble concentrations of actin monomers and Arp2/3 complex (A) Time-lapse images of bead motility assays with uncrosslinked Arp2/3 complex with fluorescence displayed at ...
monomeric Bax from LUVs and the relative stability of tetramers and hexamers, the simulation results could be better adjusted to the experimental distribution of species (Supplementary Fig. 5e,f). However, the biological implications of these tuned values should be taken with care due to the ...
Download: Download full-size image Fig. 4. Classes from negative stain EM. (A-D) The ten most populated 2D classes shown together with the resulting 3D reconstruction. 2D classes for ApoE3-lipid and ApoE380–255-lipid particles are not on the same scale as they were measured on different...
Download: Download full-size image Figure 4. RIP1 Kinase Activity Is Indispensable for Ripoptosome Formation and RIP-Mediated Cell Death (A) Etoposide-induced activation of caspases requires RIP1 kinase activity. Cells were incubated with etoposide in the presence of Nec-1 or z-VAD-fmk, and ...
Download all Document S1. Figures S1–S7 Table S1. strRNAs Predicted in This Study, Related to Figure 1 Table S2. PNCTR and PTBP1/PTBP2-Regulated Exons, Related to Figure 6 Table S3. Patient Samples Used in This Work, Related to STAR Methods Table S4. Plasmids Generated in This Stu...