The study, published on Thursday in the journal Science, has shown that scientists are able to manufacture the designed transmembrane proteins inside bacteria and mammalian cells by using as many as 215 amino acids, which are proved to be highly thermally stable and able to correctly orient themse...
(dLL37 = 3.40 nm) but still in the activating range (Supplementary Table1). This indicates that despite amino-acid changes leading to reduced membrane activity, AR23 and RV23 retain the ability to organize DNA into a four-fold square lattice. In contrast, MM1-DNA forms a ...
Inspired by self-assembling peptides found in native proteins, deliberately designed engineered peptides have shown outstanding biocompatibility, biodegradability, and extracellular matrix-mimicking microenvironments. Assembly of the peptides can be triggered by external stimuli, such as electrolytes, temperatur...
Amino acids are the building blocks of protein which perform a number of functions including catalyzing, supporting cells in ECM, DNA replication, transporting desired molecules, and so on [1]. Since late 1980s, short peptides extracted from native proteins with self-assembling properties began to...
Although widely used for the fabrication of genetically programmed biomaterials with multiple applications22, the tetrapeptide repeat proteins (TPR) have not been used as scaffolds to spatially organize multi-enzyme systems. The TPR domain is a 34 amino acid helix-turn-helix repeated motif23 that ...
Although these proteins are known to be necessary for protein processing, reverse transcription, and integration, respectively, the function of the protein thought to be Gag has not been determined. We present here the first electron microscopy of Tf1 particles. We tested whether the putative Gag ...
- 《Proteins Structure Function & Genetics》 被引量: 0发表: 2012年 Role of amino acid hydrophobicity, aromaticity, and molecular volume on IAPP(20–29) amyloid self‐assembly Aromatic amino acids strongly promote cross-β amyloid formation; whether the amyloidogenicity of aromatic residues is due...
Specific uS5-associated proteins were determined by a quantitative proteomics approach, stable isotope labeling by amino acids in cell culture (SILAC), that classifies interactions on the basis of specificity (ratio of peptide intensities between the GFP–uS5 pulldown and the control purification) ...
Functionalizing DNA nanostructures with natural cationic amino acids Complexing self-assembled DNA nanostructures with various functional guest species is the key to unlocking new and exciting biomedical applications.Cationi... D Wang,C Chen,Q Liu,... - 生物活性材料(英文) 被引量: 0发表: 2021年 ...
They minimally exhibit a β,γ-didomain architecture that has been evolutionarily repurposed in a wide range of terpene-processing enzymes and likely resulted from a fusion of unidentified monodomain proteins. Although single domain class I terpene cyclases have already been identified, the ...