Synthesis of Aspirin Lab 1: Synthesis of Aspirin Introduction: The purpose of this lab was to demonstrate the ability to easily alter the molecular structure of a compound to greatly increase its utility. In t
Furthemore, through pathway analysis and functional validation, our data reveal that aspirin may function by inhibiting protein synthesis and inducing autophagy. Additionally, confocal cell imaging using our aspirin probe was performed to examine the cellular distribution of aspirin-induced acetylation. ...
Commonly, aspirin is used as a medication for fever and inflammation, and it can be readily synthesized, even over the course of a relatively simple lab experiment. Answer and Explanation: The synthesis of aspirin proceeds by the reaction of salicylic acid...
which are widely expressed on the endothelial and epithelial cell surface [17]. Under normal conditions, ACE2 converts angiotensin II (Ang II) to Ang-(1–7), and blocks tumour growth factor (TGF-β) synthesis. However, during SARS-CoV-2 infection, ACE2 is internalized, ...
the major limitation to the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract. Preclinical studies have shown that ginger constituents ameliorate ASA-induced gastric ulceration. We here report the design and synthesis of a novel prodrug of aspirin, ...
Introduction Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explored as chemopreventive and antineoplastic agents. Aspirin...
Introduction Cardiac fibrosis is a common pathological feature of many heart diseases1. Fibrosis leads to reduced cardiac pumping capacity and abnormal heart rhythms through elevated myocardial stiffness and impaired cardiac function, and it eventually leads to heart failure2. Cardiac fibrosis has been ac...
The R/S chirality for each of the three OH groups (Figure 2A) was ensured by starting with enantiomerically pure starting materials with the same chirality and by employing synthetic transformations that retain this chirality throughout the synthesis. The Z/E geometry for each of the C = C ...
The statins competitively inhibit HMG-coenzyme A reductase, which is involved in the rate limiting step of cholesterol biosynthesis, thereby inhibits the mevalonate synthesis [6], [7]. Statins induce reduction in the LDL-C, which is milestone in the hyperlipedemia therapy, and lead to reduction...
Lab., 54, pp. 1-44, 1999. Becker et al., “Synthesis, SAR and In Vivo Activity of Novel Thienopyridine Sulfonamide Pyrrolidinones as Factor Xa Inhibitors,” Bioorganic & Medicinal Chemistry Letters, 9, pp. 2753-2758, 1999. Bertilsson, “Geographical/Interracial Differences in Polymorphic ...