42,43,44]. Ligand binding of growth factor receptors leads to autophosphorylation of RTK, which in turn leads to binding of the p85 SH2-domain to phospho-YXXM-motifs (pY; X indicating any amino acid) within the RTK. Upon this, the heterodimer dissociates...
Further, to check the involvement of Ca2+ in aspirin-induced cell death, cells were incubated with BAPTA-AM, a known chelator of Ca2+. Cell death was reduced considerably in BAPTA-treated cells (Supplementary Fig. S2). Aspirin dissociates mitochondrially bound HK-II but not HK-I. ...