The present invention, in a general and overall sense, provides a method for identifying an optimal minimal aspirin dose for a patient that is specifically tailored to the patient's specific platelet response levels (i.e., to monitor platelet in activation). The method includes measurement of th...
To analyse mechanical properties and dissolution profile, currently the pharmaceutical industry uses a well-established batch-based offline lab testing approach for quality control. Such methods are destructive, labour intensive, and time and cost consuming. In particular, dissolution testing of slow and ...
This is due to the variety of laboratory methods and cut-off values used, cohorts of different diseases analysed and the time point of analysis within the trials. We used light transmission aggregometry (LTA) the gold standard method to monitor platelet function inhibition [11]. Aspirin response...
AI is a reliable index to access the lipid contribution to the cardiovascular disease risk. Elevated AI values in the model group were mainly associated with the HFD-induced lipid orders. However, AEE showed no influence on AI index in present study, which was inconsistent with the previous res...
As an alternative to time and cost consuming lab-based testing, the potential for real-time monitor- ing and prediction of dissolution profile and mechanical properties using PAT (Process Analytical Technology) can be explored. In recent years, machine learning meth- ods have shown huge potential ...