1H and 13C NMR studies were then performed to analyze the degree of incorporation of the sialic acid-linker-amine compounds within the poly(aspartimide). These studies illustrated that the incorporation was dependent on the nature of the spacer between the sugar and the amine functionality. Thus...
Thus, using the cyclohexyl ester for aspartyl protection, our studies showed aspartimide formation could be significantly reduced to less than 2% under standard peptide synthesis conditions. Furthermore, with these model peptides, the mechanism of acid catalyzed aspartimide was studied in a range ...
Aspartimide (Asi) formation is one of the most serious side reactions that can occur both during solid phase synthesis and storage of peptides containing aspartic acid. Although numerous studies on the mechanism of Asi formation conducted so far, the problem still remains unresolved and relatively...
synthesis of this 41 aminoacid-long peptide remains a challenge owing to its three aspartic residues, all of which are prone to aspartimide formation (Asp/Asn, Asp/Asp, and Asp/Cys, Fig.5a). In addition, these residues are located close to the C-terminus, complicating the synthesis owing...
储存: Store at -20°C 库存: 现货 Background (R)-Aspartimide is a byproduct formed during solid-phase peptide synthesis (SPPS) of aspartic acid-containing peptides.1 Aspartimide is formed by cyclization of aspartic acid during Fmoc removal or peptide coupling.2 1.Ruczyński, J., Lew...
HomePeptide SynthesisSolving Aspartimide Formation in Fmoc SPPS with Fmoc-Asp(OBno)-OH Solving Aspartimide Formation in Fmoc SPPS with Fmoc-Asp(OBno)-OHAspartimide formation1,2 is caused by repeated exposure of aspartic acid containing sequences to bases...
Synthesis and characterization of new organosoluble polyaspartimides containing phosphorus Novel polyaspartimides were successfully synthesized via Michael addition reactions involving phosphorus-containing diamines and bismaleimides as monomers ... CS Wu,YL Liu,YS Chiu - 《Polymer》...
Synthesis and characterization of piperazine containing polyaspartimides blended polysulfone membranes for fuel cell applications Abstract A new polyaspartimide was synthesized via a Michael addition reaction of an aromatic bismaleimide (BMI) with aminoethylpiperazine (AEP) at 1:1 molar ratio. IR and ...
Hariharan R,Anuradha G,Bhurana S,et al.Synthesis and characterization of polyasparti mides containing anisyl moiety. Journal of Polymer Science . 2004Hariharan, R.; Anuradha, G.; Bhuvana, S.; Sarojadevi, M.; Anitha, M. Synthesis and Characterization of Polyaspartimides Containing Anisyl ...
cHex, cyclohexylHMFS, N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acidHPLC, high performance liquid chromatographyAspartimide prone sequence containing protected peptides are successfully synthesized in solid phase by using the bifunctional linker N-[(9-hydroxymethyl)-2-fluorenyl] succinamic acid (...