AST stands for “aspartate aminotransferase,” an enzyme found in several organs, including the liver. An AST blood test is part of a diagnostic process to find out if you have potential liver disease. What should I to do if my AST is high?
A previously deposited crystal structure (PDB 5C6U [https://www.rcsb.org/structure/5C6U]) identified Rv3722c as a member of the class I family of PLP-binding proteins, also referred to as the aspartate aminotransferase family5. Despite this designation, members of the class I PLP-binding/...
One-way ANOVA was used to determine the statistical differences between the means of the DSPP, AST and LDH concentration level in the three groups. A difference was considered significant when p 0.05). The high quantification of DSPP and AST levels in the severe and moderate...
FIGURE 8.Structure of an aspartate aminotransferase. The protein is a homodimer, with one covalently bound pyridoxal phosphate (shown in black) in each of the two subunits. The expanded view shows the cofactor in greater detail. [Adapted from Rhee, S.et al.(1997). “Refinement and comparisons...
Aspartate is formed from oxaloacetate by transamination with glutamate by glutamate-oxaloacetate aminotransferase (Fig. 10.14). The biosynthesis of asparagine from aspartate requires an activation via transitory phosphorylation of the terminal carboxylic group by ATP, as in the biosynthesis of glutamine (Fig...
glycine transporter type 1 OR GlyT1 OR glutamate receptor ionotropic kainate OR GRIK OR kynurenine aminotransferase OR KAT OR metabotropic glutamate receptor OR mGluR OR minocycline OR N-acetyl-aspartylglutamate OR NAAG OR N-methyl-d- aspartate OR NMDA OR pregnenolone OR sarcosine) AND controlled ...
When your doctor asks you to cough, it means you’re being checked for a hernia. Coughing tightens your stomach muscles, and when that happens someone with an inguinal hernia may find that a part of their intestines or abdominal fat starts bulging through the lower abdomen. Your doctor can ...
Aspartate aminotransferase (AST) activity and NO synthase activity were determined using kits purchased from the Nanjing Jiangcheng Bioengineering Institute. Enzyme activity of argininosuccinate synthase and fumarase was measured based on previously reported methods (Satoh et al., 2006, Tian et al., ...
2-Oxoglut, 2-oxoglutarate; ① malate/2-oxoglutarate antiporter; ② aralar 1, aspartate–glutamate carrier (SLCA12); ③ mitochondrial malate dehydrogenase; ④ mitochondrial aspartate aminotransferase (AST); ⑤ cytosolic AST; ⑥ cytosolic malate dehydrogenase. (B) Aspartate is transported into astrocytes...
Means of Solving the Problems As a result of extensive investigations, the present inventors found that a microorganism in which aspartate aminotransferase activity is decreased compared with the parent strain or deleted exhibits improved L-amino acid production efficiency, and have developed the present...