N-glycosylationOligosaccharyltransferaseSequonGlycosylation of asparagine residues is a ubiquitous protein modification. This N-glycosylation is essential in Eukaryotes, but principally nonessential in Prokaryotes (Archaea and Eubacteria), although it facilitates their survival and pathogenicity. In many ...
Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase 来自 国家科技图书文献中心 喜欢 0 阅读量: 36 作者:AP Beigneux,P Gin,BSJ Davies,MM Weinstein,A Bensadoun,RO Ryan,LG Fong,SG Young ...
Numerous protists and rare fungi have truncated Asn-tinked glycan precursors and lack N-glycan-dependent quality control (QC) systems for glycoprotein folding in the endoplasmic reticulum. Here, we show that the abundance of sequons (NXT or NXS) f which are sites for N-glycosylation of secret...
The primary structure of βNHE contains three putative N-glycosylation consensus sites (N-X-S/T) at Asn49, Asn338 and Asn378. Expression of βNHE in PS120 fibroblasts, a cell line which lacks an endogenous Na + /H + exchange, allows to determine the precise sites of glycosylation. The...
Moreover, N-linked glycans at Asn152 functioned as a recognition motif that was directly mediated by the CNX quality control system. Two phases in the retention-based ER chaperones system drove ER-localized CD147 trafficking to degradation. Deletion of N-linked glycosylation at Asn152 on CD147 ...
However, the alterations of the presence of N-glycosylation in serum RNase1 have never been reported previously with respect to PaCa. In this study, the development of anti-RNase1 antibodies that specifically recognize an unglycosylated Asn88 within RNase1 only when not N-glycosylated is reported...
Substitution of the Asn117 by Thr abolished CGRP and ADM binding in the face of intact N-glycosylation and cell surface expression. 展开 关键词: Adrenomedullin Calcitonin gene-related peptide Calcitonin receptor-like receptor Glycosylation Receptor-activity-modifying protein Tunicamycin ...
In this study we investigated the molecular mechanism of E-cadherin, which lacks N-glycosylation at Asn-633 (M4), degradation and the role of the N-glycan at Asn-633 in E-cadherin folding. We treated cells stably expressed M4 E-cadherin with MG123, DMM, respectively. Either MG132 or ...
Neuteboom, et al., The unusual amino acid triplet Asn-Ile- Cys is a glycosylation consensus site in human alpha- lactalbumin. Journal of... MG Giuffrida,M Cavaletto,C Giunta,... - 《Journal of Protein Chemistry》 被引量: 41发表: 1997年 The unusual amino acid triplet Asn-Ile-Cys is...
The sequon, Asn-X-Ser/Thr-Y, is generally required for relinked glycosylation. Pro at the X or Y position generally blocks glycosylation. We tested the impact of the X and hydroxy (Ser/Thr) amino acids by comparing the coreglycosylation of rabies virus glycoprotein variants with a single ...