Asialoglycoprotein Receptor (ASGPR): APeculiar Target of Liver-Specific Autoimmunity. Autoimmunity Highlights . 2012; 3 (3):119–125.D. Roggenbuck, M. Mytilinaiou, S. Lapin, D. Reinhold, K. Conrad, Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity, ...
Asialoglycoprotein Receptor(ASGPR)是肝细胞表面特异性表达的凝集素受体,主要功能是识别并清除去唾液酸糖蛋白。在B2B领域,该受体常用于靶向药物递送系统开发或肝病研究工具的生产。工业买家通常关注其结合活性(如半饱和浓度EC50值)、批次稳定性及适配配体(如半乳糖修饰效率)。我们平台提供多种经ELISA验证的高亲和力ASGPR...
Asialoglycoprotein receptor (ASGPR) [1] was the first animal lectin to be identified. ASGPR, which is also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor [1], the Ashwell receptor or the Ashwell–Morell receptor, is a hepatic C-type lectin. C‐type lectins are dependen...
Rabbit anti-Asialoglycoprotein Receptor 1 Recombinant Monoclonal Antibody(292-48)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明细胞定位UniProt 概述 别名 ASGP-R 1; ASGPR 1; C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1; ASGR1; CLEC4H1 ...
2.2.1The asialoglycoprotein receptor TheASGPRwas the first mammalianlectindiscovered and is a classic example of the problem of lectin-mediatedclearance mechanisms[33]. It was identified as a hepatic endocytic receptor for desialylated plasmaglycoproteinsby Ashwell, Morell, and their co-workers in ...
The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor (CI-M6PR). Here, we developed LYTACs that engage the asialoglycoprotein receptor (ASGPR), a liver-specific ...
The aim of this study was to develop reliable hepatocyte transplantation using highly proliferative, eg, progenitor-like hepatocytes, based on asialoglycoprotein receptor (ASGPR) expression levels for hepatocyte transplantation. We have previously reported that mouse hepatocytes with low ASGPR expression ...
专业医学词典 唾液酸糖蛋白受体 与"asialoglycoprotein receptor"相近的词条 ...
The asialoglycoprotein receptor is a calcium-dependent, carbohydrate-specific, type C lectin, which is majorly present in the plasma membrane of liver cells (hepatocytes). The high liver specificity, efficient internalization rate, and ready accessibility to the vasculature present great potential of ...
2.2.1 The asialoglycoprotein receptor The ASGPR was the first mammalian lectin discovered and is a classic example of the problem of lectin-mediated clearance mechanisms [33]. It was identified as a hepatic endocytic receptor for desialylated plasma glycoproteins by Ashwell, Morell, and their co...