Thus, ASH1L-AS1 might be a novel targets of GC therapeutics and diagnosis in the clinic.Mengyu,XieThe Third Affiliated Hospital of Soochow UniversityLong,ZhangLinyu,HanLinying,HuangYizhou,HuangMing,YangNasha,ZhangOncogene
Oncogene丨杨明团队揭示胃癌中ASH1L-AS1-ASH1L轴调控NME1介导的RAS信号通路激活机制 遗传和表观遗传改变导致癌基因的异常激活促进肿瘤恶性进展。 胃癌是世界上最常见的恶性肿瘤之一,也是第四大癌症死因。 已有研究证实,长非编码RNA (Long noncoding RNAs,lncRNAs) 可以招募多种表观遗传调控因子,改变靶基因组蛋白修饰,...