ASF in Eastern Europe (main clinical signs) • HYPERACUTE form • Sudden death without preliminary signs • ACUTE form § Fever of 40-42°C; § Lack of ete; § Anima re weak, lying down and huddling; DEATH or they develop the typical clinical signs (the ones...
Importin-4, NASP and RbAp46/48 form a complex with Asf1 through mutual binding to histone H3-H4 (ref. 11), and their abundances are thus expected to mirror histone binding as we observe. Previous work has shown that Asf1 distributes into a histone-bound multi- chaperone complex and a ...