Two classes of fumarases can be differentiated (Woods et al., 1988). Class I fumarases occur only in prokaryotes, are thermolabile, iron dependent, and form homodimers. Class II fumarases can be found in both prokaryotes and in eukaryotic mitochondria, they are thermostable, iron independent,...
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The tetrapyrrole biosynthetic chelatases fall into three broad classes, which vary markedly in their size and energy requirements (Fig. 1) (5). The class I chelatases require three subunits for activity and utilize ATP. Examples include the magnesium chelatase in chlorophyll and bacteriochlorophyll...
2021, Coordination Chemistry Reviews Citation Excerpt : Meanwhile the well characterised DdHydAB (from D. desulfuricans) [136] and MeHydA (from M. elsdenii) [137] contain two additional [4Fe-4S] F-clusters, bound in a bacterial ferredoxin domain, and fall into the M2 subclass (Fig. 5A an...
Inhibitors to the known classes of proteases showed no substantial inhibition of MLL processing within whole cells, providing the first suggestion that this cleavage activity would prove unique. To facilitate the characterization of the MLL protease, we generated a tractable cleavage substrate. We found...
No additional density for the Pan3 N termini can be observed in the reference free 2D classes of the full-length Pan2-Pan3 data. (B) 3D reconstruction of the Pan2cat-Pan3Δ(1-162) data with rigid body fitted models of Pan2-Pan3. The coloring scheme resembles that outlined in Figure...
(43) recently identified six classes of NLSs that specifically bind importin α. Of these, two classes (class 3 and class 4) were found to specifically bind the minor NLS-binding site of importin α. Interestingly, these two classes of NLSs have two or three basic residues, and have cons...
The most probable ancestor (mpa) comprises the most probable amino acids for all positions along the entire protein chain (for reviews see Refs. 47 and 48). Although ancestral reconstruction is an established methodology, it has caveats and limitations. For example, most reconstructions address a ...
With only one known exception [2], this reaction has so far been found to be mediated by two major classes of metalloproteins: the Ni–Fe and Fe-only hydrogenases [3], [4]. A crystallographic study of the Desulfovibrio gigas Ni–Fe enzyme has shown that, although unexpected at the time...