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To provide a contemporary guide of clinical assessments for disease monitoring and symptom management across the spectrum ofASMDphenotypes. Methods An international group of ASMD experts in various research and clinical fields used an evidence-informed consensus process to identify optimal assessments, inter...
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Study setting and participants This population-based, cross-sectional analysis comprised healthy volunteers recruited from a tertiary medical center in northern Taiwan (between July 2003 and December 2012). This study was approved by the Institutional Review Board committee on human research of the Medic...
Recent crystal structure of saposin A lipoprotein discs and cryoelectron microscopic study show sapsoin proteins can wrap around lipids and membrand protein and form lipoprotein-like nanoparticles18,24. These observations indicate saposin might be functional as long as it is under open conformation, ...
We prepared inactive rhodopsin (RhoWT), a constitutively active metarhodopsin II-mimic con- taining the M257Y mutation (Rho*; ref. 32), and the inactive apoprotein opsin (Ops; Fig. 1; structural transitions between inactive and active receptor states are reviewed in the study by Ernst et ...