Paul S. Jellinger, MD, MACE: Statin intolerance was bought up, and it's a good time to remind everyone about a recent study, a meta-analysis of 300,000 patients looking at statin intolerance, the so-called nocebo effect, which got a lot of publicity. When they dissected the true ...
statin-treated patients who experience elevations in?liver?enzymes.Here, we define how a drug and associated adverse event isclassified as a signal when using each statistical test. Using the PRR, asignal is detected, if the count of co-occurrences ≥3 and thePRR≥2.0 with an associated x2...
Hypercholesterolemic heterozygotes (LDLR+/−) showed similar characteristics as human heterozygotes (LDLR+/−) and a similar response when treated with statins (atorvastatin, 3 mg/kg/day). Homozygous (LDLR−/−) pigs also showed human-like advanced plaques and responded to statin (...